突然変異によりSARSCoV2が抗体中和に耐性を持つようになったが、ワクチンはなお意味がある: ずくなしの冷や水

2021年01月20日

突然変異によりSARSCoV2が抗体中和に耐性を持つようになったが、ワクチンはなお意味がある

※ Eric Feigl-Ding@DrEricDing氏の2021/1/20のツイート
STUNNING−South African’s CDC has made a sobering declaration:
“We now know that mutations (K417N & E484K) have allowed #SARSCoV2 to become resistant to antibody neutralization.”
“Blood samples from *1/2 tested showed all neutralizing activity* was lost.”
https://nicd.ac.za/can-i-be-re-infected-with-the-new-variant-if-ive-had-covid-19/
驚異的−南アフリカのCDCは冷静な宣言をしました:
「突然変異(K417NおよびE484K)により、#SARSCoV2が抗体中和に耐性を持つようになったことがわかりました。」
「テストされた* 血液サンプルの1/2は、すべての中和活性*が失われたことを示しました。」

2) “This suggests that they may no longer be protected from re-infection.”
画鋲 They point out that of people who had recovered from #COVID19 from the 1st wave, “90% showed reduced immunity” to the new variant #B1351 (aka 501Y.V2)
画鋲 in addition to 48% w/ “complete immune escape”

3) Why are mutations arising so fast these days??
右向き矢印
“as more people have become protected pressure on the virus has increased. A so-so spreader might no longer be able to, but variants with mutations that help them spread can take off”.

4) We’ve reached a point one year on and in certain parts of the world where the density of natural immunity is sufficient so that the variants that have got a fitness advantage … are more likely to emerge and spread,” said head of infectious diseases at Imperial College London

5) 南アフリカ国旗 data from where?
New study from blood of 44 people infected in 1st wave in S Africa南アフリカ国旗 was tested against new #SARSCoV2 variant #B1351 (501Y.V2)−found antibodies from 21 of 44 did not recognize the new variant−Almost half!
In this video:
http://youtu.be/Ja_tLG8CLAc #COVID19

6) This new E484K study is by 南アフリカ国旗’s CDC @nicd_sa
. That said, antibody immunity is not all of immunity. T cells also offer some spike protein recognizing immunity too (not measured).

Here is more studies on E484K−it’s in both 南アフリカ国旗 & Brazil ブラジル国旗 variants.

7) Support for worry about E484K? In another recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies in 9 of 11 patients, some with **10x reductions in neutralizing** ability!

8) Any other troublesome variants besides the South Africa #B1351 or the Brazil ブラジル国旗 #P1?

Maybe some suggestion of issues with the U.K. #B117 too... a 3.8x reduction in neutralization for a #B117 pseudo virus among people who got vaccine-derived immunity...

9) TO BE CLEAR−Still take the vaccine. It should not be affected too much. Maybe a few % drop in efficacy − but 80-95% is still better than 0% protection if you don’t take it!
posted by ZUKUNASHI at 14:35| Comment(0) | Covid19
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