B Vitamins in Promote Stem Cell Proliferation: ずくなしの冷や水

2016年07月19日

B Vitamins in Promote Stem Cell Proliferation

FARSNEWS2016/7/18
TEHRAN (FNA)- Folates can stimulate stem cell proliferation independently of their role as vitamins, according to a new study that used an in vitro culture and animal model system in their findings.

Folates, whether supplemental B vitamins or natural folates found in food, are essential for the proper functioning of all cells in the body and are critical to prevent birth defects.

The study in Developmental Cell, shows for the first time that an adult stem cell population is controlled by an external factor arising from outside the animal--bacterial folate. In this case, that animal was a small roundworm model organism known as Caenorhabditis elegans.

"Our study shows that germ stem cells in Caenorhabditis elegans are stimulated to divide by a specific folate that comes from their bacterial diet," said the study's co-senior author Edward Kipreos, a professor in UGA's Franklin College of Arts and Sciences. "Folates are essential B-group vitamins. However, we show that the ability of a specific folate to stimulate germ cells is independent of its role as a vitamin, implying that it acts directly as a signaling molecule."

Naturally occurring folates exist in many chemical forms; folates are found in food, as well as in metabolically active forms in the human body. Folic acid is the major synthetic form found in fortified foods and vitamin supplements.

"Since its discovery in 1945, folate has been the subject of many studies that resulted in more than 50,000 publications. The finding in this study is the first of its kind because it presents evidence that folate is involved in roles other than those that were known before," said the study's co-senior author Jacob Selhub, director of the Vitamin Metabolism Laboratory at Tufts University.
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